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Measuring Phagosome pH by Ratiometric Fluorescence Microscopy
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Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH.

Jesus S Distel1, Gisela Di Venanzio1, Joseph J Mackel2

  • 1Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

Biorxiv : the Preprint Server for Biology
|February 13, 2023
PubMed
Summary

Clinical Acinetobacter baumannii strains, unlike lab strains, persist in lung macrophages by forming specialized vacuoles. This survival mechanism, involving ammonia secretion, is crucial for respiratory infection persistence.

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