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A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S P Maher1, M A Bakowski2, A Vantaux3

  • 1Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

Biorxiv : the Preprint Server for Biology
|February 13, 2023
PubMed
Summary

New antimalarial drugs targeting Plasmodium vivax hypnozoites were identified by screening epigenetic inhibitors. These drugs target DNA methylation and histone modifications, offering new hope for radical cure treatments.

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