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Rhabdomyolysis Related to Red Yeast Rice Ingestion
Sara Santos1, Sara Gomes1, Inês Carvalho1
1Internal Medicine, Centro Hospitalar Barreiro-Montijo, Barreiro, PRT.
Abstract:
Red yeast rice is made by fermenting white rice with the fungus Monascus purpureus. It has lipid-lowering effects due to the presence of monacolin, produced by the fungus, and therefore shares the same biological and side effects as a statin, namely it may cause rhabdomyolysis. In this clinical case study, we report the case of a 50-year-old woman suffering from a sudden onset of chest discomfort and generalized myalgia. Laboratory findings were consistent with the diagnosis of rhabdomyolysis. The patient had been recently diagnosed with dyslipidemia in primary care, and decided to start eating red yeast rice, without informing clinicians. Clinical improvement was rapidly noticed after hydration, and blood sample results returned to normal. Awareness should be raised for the regulation of these products, as their consumption is rising, and patients are unaware of their potential side effects.
Insights
Red yeast rice, a supplement, can cause rhabdomyolysis, a serious muscle condition, due to its monacolin content. Patients should be aware of potential statin-like side effects from this popular supplement.
Area of Science:
- Nutritional Biochemistry
- Clinical Toxicology
Background:
- Red yeast rice is a fermented product containing monacolin, a compound with lipid-lowering properties.
- Monacolin is chemically identical to lovastatin, a statin medication used to lower cholesterol.
- Consequently, red yeast rice shares potential side effects with statins, including myotoxicity.
Observation:
- A 50-year-old woman presented with acute chest discomfort and generalized myalgia.
- She had recently been diagnosed with dyslipidemia and had started consuming red yeast rice without medical consultation.
- Her laboratory results indicated rhabdomyolysis.
Findings:
- The patient's symptoms and laboratory findings were consistent with rhabdomyolysis.
- Her condition improved rapidly following hydration, with normalization of bloodwork.
- Cessation of red yeast rice consumption was implied for recovery.
Implications:
- This case highlights the potential for serious adverse events, such as rhabdomyolysis, from red yeast rice consumption.
- Increased awareness among healthcare providers and patients regarding the risks associated with red yeast rice is crucial.
- Regulation and clear labeling of red yeast rice products are needed due to their increasing popularity and potential dangers.
