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Dissociation and association rate constants changes following bilirubin binding affinity decreases
1Laboratoire de Chimie Analytique, Faculté de Pharmacie, Université René-Descartes, Paris, France.
Developmental Pharmacology and Therapeutics
|January 1, 1987
Abstract:
The effect of sulfisoxazole, sodium salicylate, sodium cholate, urea and dimethyl sulfoxide on the kinetics of the bilirubin to human serum albumin at 24 degrees C and pH 7.40 was investigated. A marked decrease of the association constant was obtained. It was due mainly to that of the association rate constant, and might be an additional risk factor to the icteric newborn: when blood bilirubin increases, unbound bilirubin which cannot rapidly associate to albumin may reach a dangerous level, even when its equilibrium concentration is low.