Phase transferred and non-coated, water soluble perovskite quantum dots for biocompatibility and sensing

Despite the excellent optoelectronic properties exhibited by CsPbBr₃ QDs (PQDs) for sensing applications, their poor resistance to water does not allow their utilization as probes to detect analytes in aqueous media. The present work provides water soluble PQDs (dispersed in water) prepared by an appropriate phase engineering of the ligand. The dicarboxylate functional ligands at a particular pH allow the protonated state to form solvated carboxyl dimers, which interconnects PQDs, thus avoiding Ostwald ripening and enhancing the photoluminescence quantum yield (PLQY). As a proof of concept, this probe was applied to detect bioamines in water, namely histamine, hexamethylenediamine, phenethylamine, dopamine and thiamine. The probe is highly selective to histamine at concentrations below 500 nM and this selectivity of histamine over dopamine is very interesting and rarely reported. More importantly, this work offers a standard protocol for transferring PQDs from the organic to aqueous phase, for the detection of such biomolecules in water.