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Alternative splicing increases the diversity of the human protein kinase C family
L Coussens1, L Rhee, P J Parker
1Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
DNA (Mary Ann Liebert, Inc.)
|October 1, 1987
Abstract:
Isolation of two protein kinase C (PKC) cDNA clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKC beta chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (beta 1 and beta 2) that are alternatively spliced to generate two types of hPKC beta sequences. PKC beta 1 and beta 2 mRNAs are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.