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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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GLUT-Targeting Phototherapeutic Nanoparticles for Synergistic Triple Combination Cancer Therapy
Busra Cetin Ersen1, Beyza Goncu2,3, Aydan Dag4
1Institute of Graduate Programs and Department of Chemistry, Polatlı Faculty of Arts and Sciences, Ankara Hacı Bayram Veli University, Ankara 06900, Turkey.
ACS Applied Materials & Interfaces
|February 13, 2023
Summary
This study developed novel hybrid nanocarriers combining chemotherapy, photothermal therapy, and photodynamic therapy for enhanced breast cancer treatment. The multimodal nanoparticles show significant therapeutic potential for clinical applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Conventional cancer therapies often face efficacy challenges due to limitations in drug delivery and resistance.
- Multimodal therapeutic strategies offer a promising approach to overcome these limitations by combining different treatment modalities.
- Nanocarrier systems provide a platform for targeted delivery and synergistic effects of multiple therapeutic agents.
Purpose of the Study:
- To fabricate targeted, multimodal hybrid nanocarriers for enhanced breast cancer treatment.
- To integrate chemotherapy (doxorubicin), photothermal therapy (gold nanorods, indocyanine green), and photodynamic therapy into a single nanocarrier system.
- To evaluate the biocompatibility and therapeutic efficacy of the developed nanocarriers on breast cancer cells.
Main Methods:
- Synthesized gold nanorods (AuNRd) as photothermal agents.
- Coated AuNRd with a doxorubicin-conjugated, fructose-based glycopeptide polymer for targeted delivery and chemotherapy.
- Loaded indocyanine green (ICG) for photodynamic therapy and integrated antisense ISIS5132 oligonucleotides to overcome drug resistance.
- Evaluated nanoparticle performance on human normal skin fibroblast (CCD-1079Sk) and breast cancer (MCF7) cell lines.
Main Results:
- The fabricated hybrid nanocarriers (AuNRd@P-DOX/ICG/ISIS5132) demonstrated enhanced cellular uptake in breast cancer cells via GLUT5.
- The nanoparticles exhibited a synergistic triple effect combining chemotherapy, photothermal therapy, and photodynamic therapy.
- Successful prevention of apoptotic resistance was observed, indicating improved therapeutic outcomes.
Conclusions:
- The developed multimodal therapeutic nanocarrier system shows significant promise for breast cancer treatment.
- The synergistic combination of chemo-/photothermal/photodynamic therapy offers a potent strategy for overcoming therapeutic challenges.
- This nanoparticle platform has potential for further clinical translation in breast cancer and other cancers.
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