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Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial
Lidiane Rocha Mota1, Ivone da Silva Duarte2, Thais Rodrigues Galache1
1Biophotonics Applied to Health Sciences, Postgraduate Program, Universidade Nove de Julho-UNINOVE, São Paulo, Brazil.
Photobiomodulation, Photomedicine, and Laser Surgery
|February 13, 2023
Summary
Red and amber light photobiomodulation (PBM) significantly reduced facial wrinkles by approximately 30% in women aged 40-65. This safe rejuvenation technique shows promise for various patient groups, though it did not improve skin hydration or elasticity.
Area of Science:
- Dermatology and Aesthetic Medicine
- Biomedical Engineering
- Photomedicine
Background:
- Growing demand for non-invasive cosmetic procedures for skin aging.
- Photobiomodulation (PBM) with red and amber light shows potential for collagen synthesis.
- Limited comparative studies on different wavelengths at identical doses for periocular wrinkles.
Purpose of the Study:
- To compare the efficacy of red and amber light-emitting diode (LED) photobiomodulation (PBM) for facial rejuvenation.
- To evaluate wrinkle volume, skin hydration, elasticity, and quality of life.
- To assess these outcomes at the same light dose for both wavelengths.
Main Methods:
- Split-face, randomized clinical trial with 137 women (40-65 years old, phototypes II-IV, Glogau II-IV).
- 10 sessions over 4 weeks of red (660 nm) and amber (590 nm) PBM (3.8 J/cm²) applied bilaterally.
- Outcomes measured included periocular wrinkle volume, skin hydration, elasticity, and quality of life via validated questionnaires.
Main Results:
- Significant reduction in wrinkle volume: 31.6% for red PBM and 29.9% for amber PBM.
- No significant improvements in skin hydration or viscoelasticity were observed.
- Participants reported enhanced quality of life based on MelasQoL-BP and Skindex-29 questionnaires.
Conclusions:
- Photobiomodulation using both red and amber wavelengths is effective for facial rejuvenation, achieving substantial wrinkle reduction.
- The technique is a safe alternative for patients with contraindications to inflammatory procedures, such as those with diabetes or keloids.
- While not improving hydration or elasticity, PBM offers a valuable non-invasive option for enhancing skin appearance and patient well-being.
