Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Clomipramine-induced urinary dysfunction in an obsessive-compulsive adolescent.

H Hermesh¹, D Aizenberg, A Weizman

¹Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.

Drug Intelligence & Clinical Pharmacy

|November 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Insight into the current practice of ototoxicity monitoring during cisplatin therapy.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2021

Same author

Effects of country of origin and wave of immigration on prevalence of schizophrenia among first and second-generation immigrants: A 30-year retrospective study.

Schizophrenia research·2020

Same author

The interaction between neurocognitive functioning, subthreshold psychotic symptoms and pharmacotherapy in 22q11.2 deletion syndrome: A longitudinal comparative study.

European psychiatry : the journal of the Association of European Psychiatrists·2018

Same author

The Effectiveness of a Knowledge Translation Cognitive-Educational Intervention for Family Members of Persons Coping with Severe Mental Illness.

Community mental health journal·2017

Same author

CD44 Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like Behavior in Mice.

Journal of molecular neuroscience : MN·2016

Same author

Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease.

Cell death discovery·2016

Clomipramine, used for obsessive-compulsive disorder, can cause urinary retention in adolescents. This side effect, linked to dosage, may involve noncholinergic and nonadrenergic pathways, necessitating drug discontinuation.

Area of Science:

Pharmacology
Adverse Drug Reactions
Adolescent Medicine

Background:

Obsessive-compulsive disorder (OCD) is a mental health condition often treated with selective serotonin reuptake inhibitors (SSRIs).
Clomipramine is a tricyclic antidepressant (TCA) with SSRI properties, effective for OCD but associated with various side effects.
Urinary retention is a known, albeit less common, anticholinergic side effect of TCAs.

Observation:

A 15-year-old male experienced two episodes of urinary retention after starting clomipramine for OCD.
Both the therapeutic effects and side effects of clomipramine, including urinary retention, were dose-dependent.
The severity of the urinary retention was significant, showing resistance to treatments like bethanechol and phenoxybenzamine.

Findings:

Related Experiment Videos

This case highlights that clomipramine-induced urinary retention can occur in adolescents, not exclusively in older populations.
The adverse drug reaction necessitated complete cessation of clomipramine treatment.
The resistance to standard pharmacological interventions suggests potential noncholinergic and nonadrenergic mechanisms contributing to the retention.

Implications:

Clinicians should be vigilant for urinary retention as a potential side effect of clomipramine in adolescent patients.
Dosage adjustments and careful monitoring are crucial when prescribing clomipramine to younger individuals.
Further research may be warranted to elucidate the specific noncholinergic and nonadrenergic pathways involved in clomipramine-induced urinary retention.