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The regulation roles of miRNAs in Helicobacter pylori infection

Ting Tong1,2,3, You Zhou1,2,3, Qiaoling Huang1,2,3

  • 1Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|February 13, 2023
PubMed

Insights

Helicobacter pylori infection alters microRNA expression in host cells. These microRNAs regulate cell behaviors like proliferation and apoptosis through various signaling pathways, impacting gastrointestinal health.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Helicobacter pylori is a Gram-negative bacterium infecting human gastric mucosa.
  • H. pylori infection is linked to gastrointestinal diseases like gastritis, ulcers, and gastric cancer.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating crucial cellular processes.

Purpose of the Study:

  • To review the regulatory role of microRNAs in host cell biological behavior following H. pylori infection.
  • To explore the signaling pathways involved in miRNA-mediated regulation.
  • To understand how altered miRNA expression impacts cellular processes during H. pylori infection.

Main Methods:

  • Literature review of studies investigating miRNA expression and function in H. pylori-infected cells.
  • Analysis of research on miRNA-mediated regulation of host cell proliferation, differentiation, autophagy, apoptosis, and inflammation.
  • Examination of identified signaling pathways influenced by miRNAs in the context of H. pylori infection.

Main Results:

  • H. pylori infection demonstrably alters the expression levels of specific microRNAs in host cells.
  • These dysregulated microRNAs modulate key cellular functions, including cell cycle control and inflammatory responses.
  • Various signaling pathways are implicated in the miRNA-dependent biological responses to H. pylori.

Conclusions:

  • MicroRNAs play a significant role in mediating the host cell's response to H. pylori infection.
  • Understanding miRNA regulation offers potential therapeutic targets for H. pylori-associated diseases.
  • Further research into miRNA-pathway interactions is crucial for developing effective treatment strategies.
Keywords:
ApoptosisHelicobacter pyloriInflammationMicroRNAsSignaling pathways

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