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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids

Alex Reed1, Timothy Ware1, Haoxin Li1

  • 1Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA.

Nature Chemical Biology
|February 13, 2023
PubMed
Summary

Researchers identified TMEM164 as an enzyme crucial for producing polyunsaturated fatty acid ether phospholipids (PUFA-ePLs), which drive ferroptosis. Its absence selectively reduces PUFA-ePLs, offering variable protection against this cell death pathway.

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