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Related Experiment Video

Updated: Aug 10, 2025

Microscopy of Fission Yeast Sexual Lifecycle

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

Phase separation in fungi.

Mae I Staples¹, Corey Frazer¹, Nicolas L Fawzi²

¹Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.

Nature Microbiology

|February 13, 2023

Summary

This summary is machine-generated.

Phase separation drives key fungal cell processes, from gene regulation to signaling. This review explores how these molecular condensates impact fungal biology and evolution.

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Last Updated: Aug 10, 2025

Microscopy of Fission Yeast Sexual Lifecycle

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Area of Science:

Cell Biology
Molecular Biology
Mycology

Background:

Phase separation is a fundamental cellular mechanism where macromolecules form distinct liquid or solid-like compartments.
This process is crucial for organizing cellular functions across all life forms.
Understanding phase separation in fungi is vital due to their unique biological roles.

Purpose of the Study:

To review the principles of phase separation.
To highlight its impact on diverse cellular processes within the fungal kingdom.
To showcase research in model yeasts and fungal pathogens.

Main Methods:

Literature review of phase separation principles and fungal cell biology.
Analysis of examples of stable and transient phase-separated assemblies in fungi.
Synthesis of findings from model yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe) and fungal pathogens (Ashbya gossypii, Candida albicans).

Main Results:

Phase separation regulates critical fungal processes including autophagy, cell signaling, transcriptional regulation, and cellular asymmetry.
Examples include stable membraneless organelles (e.g., nucleolus) and transient condensates.
These condensates allow rapid and reversible cellular responses to environmental cues.

Conclusions:

Phase separation is a conserved and essential mechanism in fungal biology.
Research in diverse fungal species continues to deepen our understanding of fundamental molecular processes.
Phase separation offers insights into cellular organization, regulation, and adaptation in fungi.