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Brain-derived neurotrophic factor associated with kidney function.

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Fasting brain-derived neurotrophic factor (BDNF) levels indicate chronic kidney disease (CKD) risk, with higher levels correlating to lower prevalence. Specific BDNF gene variants also show significant associations with CKD susceptibility.

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Area of Science:

  • Neuroscience
  • Nephrology
  • Genetics

Background:

  • Chronic kidney disease (CKD) is a growing global health concern.
  • Brain-derived neurotrophic factor (BDNF) plays crucial roles in neuronal health and may be implicated in CKD pathogenesis.

Purpose of the Study:

  • To investigate the association between serum BDNF levels and CKD.
  • To explore the relationship between BDNF gene variants and CKD susceptibility.

Main Methods:

  • Cross-sectional study of 480 participants without diabetes, including oral glucose tolerance tests (OGTT) and serum BDNF measurements at fasting, 30, and 120 minutes.
  • Case-control genetic analysis of 3003 participants to assess the association of BDNF gene variants with CKD.

Main Results:

  • Higher fasting serum BDNF quartiles were significantly associated with lower CKD prevalence (P < 0.001).
  • Fasting BDNF levels demonstrated superior diagnostic ability for CKD compared to post-glucose challenge levels.
  • Specific BDNF gene variants (rs12098908, rs12577517, rs72891405) were significantly associated with CKD.

Conclusions:

  • Fasting BDNF levels are an independent indicator of CKD.
  • BDNF levels measured post-glucose intake do not show a significant association with CKD.
  • Genetic variations in BDNF are linked to CKD susceptibility.