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Ventricular arrhythmias during exercise in patients with heart failure: the effect of amiodarone
1Department of Cardiology, Western Infirmary, Glasgow, UK.
Abstract:
In a group of 62 patients with chronic heart failure 29% developed ventricular tachycardia during exercise testing. The two-year survival of this group was only 22%, compared to 55% in those not demonstrating ventricular tachycardia (P less than 0.01). In a double-blind cross-over study against placebo, with three-month treatment periods, amiodarone, in a dose of 200 mg day-1, was found effectively to suppress ventricular arrhythmias during exercise and in the immediate post-exercise period. Exercise performance was not impaired. Amiodarone may be useful in preventing life-threatening arrhythmias in patients with heart failure.
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