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Related Experiment Videos

Cell membrane, a target for steroid hormones.

E E Baulieu

    Molecular and Cellular Endocrinology
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Hormone-membrane interactions in somatic cells are possible, potentially alongside classical receptors. This review examines steroid interactions with cell membranes to assess their broader significance beyond oocytes.

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    Area of Science:

    • Endocrinology
    • Cell Biology
    • Molecular Biology

    Background:

    • Limited evidence currently supports hormone-membrane interaction mechanisms in somatic target cells.
    • Hormones may possess multiple molecular targets within a single cell, including membrane-associated sites.
    • Classical receptor systems may operate in conjunction with membrane-level hormone interactions.

    Purpose of the Study:

    • To review existing studies on target cell membrane interactions with steroids.
    • To investigate the potential significance of hormone-membrane interactions in somatic cells.
    • To determine if oocyte-observed interactions have wider applicability.

    Main Methods:

    • Review of scientific literature focusing on steroid-membrane interactions.
    • Analysis of studies utilizing modified steroids that prevent intracellular entry.

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  • Comparative assessment of interactions observed in oocytes versus other somatic cells.

    • Main Results:

    • The review explores studies where steroids interact with cell membranes without entering the cell.
    • Evidence is evaluated to determine if these membrane interactions are a common phenomenon.
    • The significance of these interactions in the context of broader cellular signaling is considered.

    Conclusions:

    • Hormone-membrane interactions represent a plausible, though not yet widely evidenced, mechanism in somatic cells.
    • Such interactions could function independently or complement classical intracellular receptor pathways.
    • Further research is warranted to elucidate the scope and significance of steroid-membrane interactions.