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Updated: Aug 10, 2025

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids
Published on: June 16, 2023
Laser Ablation Synthesis in Solution and Nebulization of Silver-109 Nanoparticles for Mass Spectrometry and Mass
Aneta Płaza1, Artur Kołodziej1, Joanna Nizioł2
1Doctoral School of Engineering and Technical Sciences at the Rzeszów University of Technology, 8 Powstańców Warszawy Ave., Rzeszów 35-959, Poland.
Abstract:
Preparation of monoisotopic silver-109 nanoparticles (109AgNPs) by pulsed fiber laser (PFL) ablation synthesis in solution (LASiS) with the use of a 2D galvoscanner (2D GS) is described. The procedure of covering of custom-made stainless-steel MALDI targets containing studied objects via nebulization is also presented. Examples of application of the new method (PFL-2D GS LASiS and nebulization) in mass spectrometry (MS) analyses and MS imaging (MSI) are shown. These include tests with a nonionic nucleoside and saccharide, ionic amino acids, and also a low-molecular-weight polymer. Fingerprint MS imaging is shown as an example of a fast and simple MSI procedure.
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