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Hypertrophic cardiomyopathy is associated with dilated sinus of Valsalva: A case-control study

Ji Ae Yoon1, Mirza Mujadil Ahmad1, Afshan Husain1

  • 1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Advocate Aurora Health, 2801 W. Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI 53215, USA.

International Journal of Cardiology. Heart & Vasculature
|February 14, 2023
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is linked to a dilated sinus of Valsalva. This association between HCM and aortic dilation persists after accounting for other factors, suggesting a potential connection.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Aortic dilation, particularly of the sinus of Valsalva, is a concern in cardiovascular health.
  • The relationship between HCM and aortic dimensions requires further investigation.

Purpose of the Study:

  • To investigate the association between hypertrophic cardiomyopathy and aortic dilation.
  • To determine if a dilated sinus of Valsalva is more prevalent in HCM patients compared to controls.

Main Methods:

  • A matched case-control study was conducted using echocardiographic data.
  • 153 patients with HCM were compared to 153 matched controls without known risk factors for aortic dilation.
  • Dilated aorta was defined using established clinical and imaging criteria.

Main Results:

  • The prevalence of a dilated sinus of Valsalva was significantly higher (9.4 times) in HCM patients than in controls (P = 0.003).
  • This association remained significant after adjusting for height, weight, and aortic pathology.
  • Dilated mid-ascending aorta showed a significant association with HCM after adjustments for height and body surface area.

Conclusions:

  • Hypertrophic cardiomyopathy is associated with a dilated sinus of Valsalva.
  • The findings suggest a potential link between HCM and aortic root abnormalities.
  • Further research is warranted to elucidate the underlying mechanisms of this association.
Abstract

Keywords:
Hypertrophic cardiomyopathySinus of ValsalvaThoracic aorta aneurysm

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