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Predictive value of serum iron on heart failure in patients with acute ST-segment elevation myocardial infarction

Wen Chen1, Guoli Lin1, Caizhi Dai1

  • 1Department of Cardiology, The Affiliated Hospital of Putian University, Putian University, Fujian, China.

Clinical Cardiology
|February 14, 2023
PubMed

Insights

Lower serum iron levels are a significant risk factor for developing heart failure after acute ST-segment elevation myocardial infarction (STEMI). Early prediction of heart failure post-STEMI may benefit from monitoring serum iron.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Medicine

Background:

  • Heart failure frequently complicates acute myocardial infarction, necessitating early predictive biomarkers.
  • Acute ST-segment elevation myocardial infarction (STEMI) is a critical condition often leading to heart failure.
  • Identifying novel biomarkers for early heart failure prediction post-STEMI is crucial for clinical practice.

Purpose of the Study:

  • To investigate the association between serum iron levels and the incidence of heart failure following STEMI.
  • To evaluate serum iron as a potential predictive biomarker for heart failure in STEMI patients.

Main Methods:

  • A cohort study included 41 patients with heart failure post-STEMI and 31 control subjects.
  • Demographic and clinical characteristics were analyzed.
  • Binary logistic regression and receiver operating characteristic (ROC) analyses were performed to assess predictive values.

Main Results:

  • Serum iron levels were significantly lower in patients with heart failure post-STEMI compared to controls.
  • Serum iron and Troponin I (Tn-I) were identified as independent predictors of heart failure post-STEMI.
  • ROC analysis indicated serum iron has a significant area under the curve (0.808), with an optimal cutoff of 11.87 μmol/L.

Conclusions:

  • Reduced serum iron levels are associated with an increased risk of heart failure after STEMI.
  • Serum iron serves as a potential independent risk factor and predictive biomarker for heart failure in STEMI patients.
  • Monitoring serum iron may aid in the early identification of patients at high risk for heart failure post-STEMI.
Abstract

Keywords:
acute ST-segment elevation myocardial infarctionheart failureserum iron

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