Related Experiment Video
Updated: Aug 10, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Identification and management of connective tissue disease-associated interstitial lung disease: evidence-based
Masataka Kuwana1, Masashi Bando2, Yutaka Kawahito3
1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
Insights
Expert consensus statements and an algorithm were developed to guide the management of interstitial lung disease (ILD) in patients with connective tissue disease (CTD). This provides crucial clinical guidance for CTD-ILD.
Area of Science:
- Rheumatology
- Pulmonology
- Radiology
- Pathology
Background:
- Interstitial lung disease (ILD) frequently complicates connective tissue diseases (CTD).
- Limited clinical trials exist to guide the management of CTD-ILD.
- Developing expert consensus is crucial for effective CTD-ILD patient care.
Purpose of the Study:
- To develop expert consensus statements for managing CTD-ILD.
- To create a clinical algorithm for CTD-ILD management.
- To provide evidence-based guidance for physicians treating CTD-ILD.
Main Methods:
- A targeted literature review informed statement development.
- A modified Delphi process surveyed 22 Japanese physicians.
- Two rounds of web-based surveys established consensus on management statements.
Main Results:
- Consensus was reached on 93 statements regarding CTD-ILD management.
- Key consensus areas include ILD screening in CTD patients, diagnostic methods (imaging, PFTs, biomarkers), regular follow-up, and multidisciplinary care.
- Consensus statements were translated into a practical clinical algorithm.
Conclusions:
- Expert consensus statements and a clinical algorithm for CTD-ILD management have been successfully developed.
- This Delphi-based approach provides a framework for clinical decision-making in CTD-ILD.
- The developed algorithm aims to standardize and improve the care of patients with CTD-ILD.
Background:
Interstitial lung disease (ILD) is a common complication of connective tissue diseases (CTD), but there are few clinical trials to guide disease management. We aimed to develop expert consensus statements and an algorithm for CTD-ILD management.
Research Design And Methods:
Based on a targeted literature review, we developed 109 statements on managing CTD-ILD across six domains. We used a modified Delphi process to survey 22 physicians in Japan involved in managing CTD-ILD (specialists in pulmonology, rheumatology, pathology, and radiology). These panelists participated in two rounds of web-based survey to establish consensus statements, which were used to define an algorithm. Consensus was defined as a mean value ≥70 on a scale of 0 (strong disagreement) to 100 (strong agreement).
Results:
Between May-August 2022, consensus was reached on 93 statements on CTD-ILD management. The most important consensus statements included screening CTD patients for ILD (typically with high-resolution computed tomography), using imaging, pulmonary function testing and serum biomarkers for diagnosis and severity assessment, regularly following up patients, and multidisciplinary management of CTD-ILD. Consensus statements were interpreted into an algorithm for clinical guidance.
Conclusions:
Using the Delphi process, we have developed consensus statements and an algorithm to guide clinical decision-making for CTD-ILD.
More Related Videos
06:15Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Related Concept Videos
01:29Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:30Chronic Obstructive Pulmonary Disease-V: Nursing Management
Assessment
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care