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Research Progress in Small Molecules as Anti-vitiligo Agents

Heng Wu^1,2, Chao Niu^1,2, Haji Akber Aisa^1,2

¹Key Laboratory of Chemistry of Plant Resources in Arid Regions，Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.

Current Medicinal Chemistry

|February 14, 2023

Abstract

None:

Vitiligo is a disease characterized by skin discoloration, and no safe and effective drugs have been developed until now. New drug research and development are imminent. This article reviews the research on small-molecule drugs for vitiligo from 1990 to 2021 at home and abroad. They are classified according to their structures and mechanisms of action, including natural products and derivatives, anti-oxidative stress drugs, immunosuppressants, prostaglandins, etc. The research on their anti-vitiligo activity, structural modification, new dosage forms, clinical trials, and the development trend in new anti-vitiligo drugs are reviewed, which provides important references for the development of new drugs.

Keywords:

L-tyrosine Vitiligo immunosuppression melanin production melanocytes prostaglandin small molecule drugs

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