Related Experiment Video
Updated: Aug 10, 2025
08:54
Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
Published on: May 20, 2020
9.2K
When benign leiomyomas metastasize to the lungs - a case report
Joana Vieira Naia1, Diana Pimenta2, Anita Paiva3
1Pulmonology Department, Hospital of Braga. joanavnaia@gmail.com.
Summary
Benign metastasizing leiomyoma is a rare condition causing lung tumors in women with a history of uterine fibroids. This case highlights diagnosis and treatment in an older patient.
Area of Science:
- Gynecologic Oncology
- Pulmonary Medicine
- Pathology
Background:
- Benign metastasizing leiomyoma (BML) is a rare neoplastic disease.
- It primarily affects premenopausal women with a history of uterine leiomyoma.
- Pulmonary metastases characterize this condition, with largely unknown pathogenesis.
Observation:
- Patients are often asymptomatic or present with vague symptoms like persistent dry cough.
- Diagnosis requires pathological examination and immunohistochemistry.
- A 72-year-old woman with a history of hysterectomy presented with a dry cough and pulmonary nodules.
Findings:
- Computed tomography revealed multiple small pulmonary nodules.
- Surgical biopsy confirmed benign metastasizing leiomyoma.
- Letrozole treatment was initiated and well-tolerated.
Implications:
- This case expands the understanding of BML presentation in postmenopausal women.
- It underscores the importance of histopathological diagnosis for rare pulmonary lesions.
- Hormonal therapy, such as letrozole, may be a viable treatment option.
