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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Choosing nasal devices: a dilemma in clinical practice
Attilio Varricchio1, Francesco Brunese2, Ignazio La Mantia3
1. attilio.varricchio@aivas.it.
Acta Bio-Medica : Atenei Parmensis
|February 14, 2023
Summary
Choosing the right nasal delivery device is crucial for treating upper airway diseases. This study compared five devices, finding significant differences in how well they distribute medication within the nasal cavity.
Area of Science:
- Otolaryngology
- Pharmacology
- Medical Devices
Background:
- Upper airway diseases are common, with diverse causes like infection, inflammation, and allergies.
- Topical treatments are preferred over systemic medications for these conditions.
- Various nasal drug delivery devices exist, but optimal usage requires understanding their efficacy.
Purpose of the Study:
- To compare the intranasal distribution of saline solution with methylene blue using five different delivery devices.
- To inform clinical practice regarding the selection of appropriate nasal drug delivery systems.
Main Methods:
- Five nasal delivery devices were evaluated: nasal dropper, standard nasal spray, mucosal atomization device, nebulizer, and nasal douche.
- A saline solution containing methylene blue was used as a marker to assess distribution.
- Intranasal distribution patterns were visually compared across devices.
Main Results:
- Significant variations in the area of distribution were observed among the tested nasal delivery devices.
- The study highlighted differences in the extent and pattern of intranasal spread for each device.
Conclusions:
- The choice of nasal delivery device significantly impacts medication distribution.
- Clinicians should select the most suitable device based on the specific upper airway disease and desired distribution pattern.
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