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Updated: Aug 10, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Planet-compatible pathways for transitioning the chemical industry.

Fanran Meng¹, Andreas Wagner², Alexandre B Kremer²

¹Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, UK.

Proceedings of the National Academy of Sciences of the United States of America

|February 14, 2023

Summary

Achieve sustainable chemical production by 2050 through resource efficiency and circular economy strategies. These planet-compatible pathways reduce demand, shift feedstocks, and decarbonize energy for net-negative emissions.

Keywords:

chemicals circularity climate change fertilizers plastics

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Area of Science:

Environmental Science
Chemical Engineering
Sustainable Chemistry

Background:

Modern lifestyles depend on chemical products like plastics and fertilizers.
Chemical production, use, and disposal cause significant environmental damage.
The chemical industry faces challenges to its operational sustainability due to environmental impacts.

Purpose of the Study:

To present seven planet-compatible pathways for the chemical industry to achieve sustainability by 2050.
To explore demand-side and supply-side interventions for environmental impact mitigation.
To estimate the investment costs associated with these sustainable pathways.

Main Methods:

Modeling of demand-side interventions focusing on resource efficiency and circularity.
Analysis of supply-side interventions including feedstock replacement and energy decarbonization.
Calculation of cumulative investment costs for proposed pathways.

Main Results:

Resource efficiency and circularity can decrease global chemical demand by 23–33%.
Transitioning to biogenic/air-capture sources and decarbonizing energy can lead to net-negative emissions.
Proposed interventions could achieve net-negative emissions of 0.5 GtCO2eq y-1 for non-ammonia chemicals.

Conclusions:

Implementing resource efficiency and circular economy principles is crucial for sustainable chemical production.
Shifting to sustainable feedstocks and decarbonizing energy are key to achieving net-negative emissions.
The chemical industry can maintain essential services while significantly reducing its environmental footprint.