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Updated: Aug 10, 2025
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Waldenstrom Macroglobulinemia Arising During Maintenance Therapy of Plasma Cell Myeloma
Background:
Both plasma cell myeloma (PCM) and Waldenstrom's macroglobulinemia (WM) are mature B-cell neoplasms commonly involving bone marrow and usually related to paraproteinemia.
Methods:
Secondary WM in a patient with PCM during maintenance therapy has not been previously reported. We herein report the first case of WM arising during maintenance therapy of PCM.
Results:
The diagnosis of secondary WM during maintenance therapy of PCM was based on combination of medical history, morphology, flow cytometry, immunofixation electrophoresis, and molecular genetics.
Conclusions:
This case highlights the importance of an integrated diagnostic work-up, with an interesting role for morphology and flow immunotyping.
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