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Updated: Aug 10, 2025

In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells
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RNA modification in mRNA cancer vaccines

Yingxue Mei1, Xiang Wang2

  • 1Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, 116044, Liaoning, People's Republic of China.

Clinical and Experimental Medicine
|February 14, 2023
PubMed
Summary

RNA modifications enhance messenger RNA (mRNA) vaccine efficacy and safety by reducing instability and immunogenicity. This review explores RNA modification functions and their crucial role in advancing mRNA cancer vaccines and personalized therapies.

Keywords:
Combination therapyImmunogenicityImmunotherapyRNA methylationRNA modificationmRNA cancer vaccine

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