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Related Experiment Video

Updated: Aug 10, 2025

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Exploring patient experience and satisfaction with depot buprenorphine formulations: A mixed-methods study.

Eve Allen1, Sona Samadian2,3, Gary Altobelli2,3

  • 1UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.

Drug and Alcohol Review
|February 14, 2023
PubMed
Summary

Depot buprenorphine offers improved convenience and reduced stigma for opioid dependence treatment. However, some patients experienced mixed efficacy and disconnection from healthcare services.

Keywords:
buprenorphineopiate substitution treatmentopioid-related disordersqualitative researchsocial stigma

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Area of Science:

  • Pharmacology and Addiction Medicine
  • Patient-Reported Outcomes
  • Public Health Services

Background:

  • Depot buprenorphine offers reduced dosing frequency compared to oral methadone and sublingual buprenorphine-naloxone for opioid dependence.
  • Reduced frequency may mitigate issues like cost, pharmacy attendance, stigma, and diversion risk associated with conventional Medication Assisted Treatment for Opioid Dependence (MATOD).

Purpose of the Study:

  • To explore patient experiences with depot buprenorphine in an Australian public drug and alcohol service.
  • To understand the perceived benefits and drawbacks of this long-acting formulation.

Main Methods:

  • Mixed-methods study involving quantitative verbal surveys and qualitative interviews.
  • Twenty-eight participants were recruited from a publicly operated drug and alcohol service over a 5-week period in 2021.

Main Results:

  • Majority satisfaction reported with depot buprenorphine regarding efficacy, convenience, and overall experience.
  • Perceived benefits include enhanced convenience, reduced stigma, and prevention of missed doses.
  • Mixed experiences noted regarding sustained efficacy throughout the dosing interval; some reported disconnection from healthcare.

Conclusions:

  • Patient perceptions are influenced by prior experiences with conventional MATOD treatments.
  • Depot buprenorphine is largely viewed as socially, personally, and financially beneficial.
  • Potential for service disconnection and variable efficacy requires consideration for optimizing patient experience.