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Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Related Experiment Video

Updated: Aug 10, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Peptide-based Self-assembly: Design, Bioactive Properties, and Its Applications.

He Diao¹, Yunhua Lu², Yun Ling³

¹School of Life Science and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.

Current Pharmaceutical Design

|February 15, 2023

Summary

Peptide self-assembly offers versatile solutions for drug delivery, tissue engineering, and therapeutic agents. Engineering these peptide assemblies shows significant promise for advancing medical applications.

Keywords:

Peptides antibacterial agents biomedicine drug delivery self-assembly tissue engineering

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Published on: November 21, 2013

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Published on: September 6, 2024

Area of Science:

Biomaterials Science
Nanotechnology
Chemical Biology

Background:

Peptide self-assembly is a rapidly growing area in biomedical research.
Peptide assemblies are explored for drug/gene delivery, tissue engineering, and as antibacterial/anticancer agents.

Approach:

This review describes the structure and function of peptide self-assembly.
It highlights advances in peptide-based self-assembly for various biomedical applications.

Key Points:

Morphology and structure are tunable via molecular design and assembly conditions.
Applications include drug packaging/delivery, tissue engineering, antibacterial agents, siRNA delivery, and vaccines.

Conclusions:

Engineering peptide assemblies holds immense potential for medical fields.
Challenges and future perspectives in polypeptide self-assembly are discussed.