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Advances in Polysaccharide-Based Oral Colon-Targeted Delivery Systems: The Journey So Far and the Road Ahead

Ibrahim M Ibrahim1

  • 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.

Cureus
|February 15, 2023
PubMed

Insights

Polysaccharide-based colon-targeted delivery systems offer promise for colorectal diseases. However, reduced bacterial counts during illness can hinder drug release, necessitating further research for clinical application.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Colorectal Therapeutics

Background:

  • Oral colon-targeted delivery systems are crucial for treating colorectal diseases.
  • Polysaccharide-based systems are promising due to selective colonic bacterial digestion.
  • A key limitation is reduced bacterial count during disease, impairing drug release.

Purpose of the Study:

  • To review various oral colon-targeted delivery systems.
  • To detail the benefits and limitations of polysaccharide-based systems.
  • To highlight challenges in clinical application and scalability.

Main Methods:

  • Review of existing literature on colon-targeted drug delivery.
  • Analysis of polysaccharide-based systems and their mechanisms.
  • Discussion of factors affecting microflora-triggered systems.

Main Results:

  • Polysaccharide systems are effective when colonic bacteria are abundant.
  • Disease states can compromise the efficacy of these systems.
  • Probiotic co-administration shows potential but requires further study.

Conclusions:

  • Polysaccharide-based colon-targeted delivery systems require further development for clinical use.
  • Addressing bacterial count reduction is critical for system reliability.
  • Scalable and clinically applicable solutions are needed for widespread adoption.
Keywords:
colon-targeted drug deliverycolorectal diseasesdissolution methodsgut microbiotaoral drug delivery

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