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Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Updates on Surgical Treatment for Gastroesophageal Reflux Disease
Katherine Kendrick1, Shanu N Kothari2
1Department of Gastroenterology and Hepatology, Prisma Health Upstate-Greenville Memorial Hospital, Greenville, SC, USA.
Abstract:
Gastroesophageal reflux disease (GERD) is a common condition that is on the rise. Obesity is one risk factor that has increased in parallel with the rise of GERD. Typical symptoms include heartburn, regurgitation, dysphagia, cough, and chest pain. Patients with typical symptoms are empirically treated with proton pump inhibitors (PPIs). If the diagnosis is not clear, further evaluation is performed with endoscopy, pH monitoring, and esophageal manometry. Untreated GERD increases the risk of esophagitis, esophageal stricture, Barrett's esophagus, and esophageal adenocarcinoma. Treatment begins with lifestyle modification and medical therapy. If these fail, surgical and endoscopic surgical techniques are available, to provide treatment, symptom relief, and reduce long-term PPI use.
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