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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Distinct Mutagenic Activity of APOBEC3G Cytidine Deaminase Identified in Bladder Cancer

Deborah Caswell1, Charles Swanton1

  • 1Cancer Evaluation and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.

Cancer Research
|February 15, 2023
PubMed

Insights

APOBEC3G (A3G) promotes bladder cancer and creates a distinct mutational signature. This signature is linked to poorer survival in urothelial carcinoma patients, highlighting A3G

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • The APOBEC cytidine deaminase family is implicated in cancer mutational signatures.
  • Previous research focused on APOBEC3A and APOBEC3B, leaving other family members understudied.
  • Understanding diverse APOBEC roles is crucial for cancer research.

Discussion:

  • Liu and colleagues explored APOBEC3G's (A3G) role in bladder cancer.
  • Transgenic A3G expression in a mouse model accelerated tumor development.
  • A unique A3G-induced mutational signature was identified, differing from known APOBEC signatures.

Key Insights:

  • The A3G-related mutational signature correlates with worse survival in urothelial bladder carcinoma.
  • APOBEC3G expression was detected across 21 distinct cancer types.
  • Different APOBEC3 enzymes generate unique signatures and influence cancer evolution.

Outlook:

  • Further investigation into individual APOBEC3 enzyme functions is warranted.
  • This research contributes to a deeper understanding of cancer mutagenesis.
  • Elucidating APOBEC3 roles may lead to improved anticancer therapies.

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