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Related Concept Videos

Renal Regulation of Acid-Base Balance01:29

Renal Regulation of Acid-Base Balance

555
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
555

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Related Experiment Video

Updated: Aug 10, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
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Published on: April 25, 2025

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Causal associations between polyunsaturated fatty acids and kidney function: A bidirectional Mendelian randomization

Yingyue Huang1, Jiao Wang1, Huiling Yang2

  • 1School of Public Health, Sun Yat-sen University, Guangzhou, China.

The American Journal of Clinical Nutrition
|February 15, 2023
PubMed
Summary

Higher intake of omega-6 fatty acids and linoleic acid (LA) may increase estimated glomerular filtration rate (eGFR), suggesting a potential benefit for kidney function. Further research is warranted to confirm these findings.

Keywords:
Mendelian randomizationchronic kidney diseaseestimated glomerular filtration rateomega-3omega-6polyunsaturated fatty acids

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Area of Science:

  • Nutritional Epidemiology
  • Nephrology
  • Genetics

Background:

  • Observational studies suggest polyunsaturated fatty acids (PUFAs) benefit kidney function.
  • Causal relationships between PUFAs and kidney disease remain unclear.

Purpose of the Study:

  • To investigate the causal effect of PUFAs on chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR).
  • Utilized bidirectional 2-sample Mendelian randomization (MR).

Main Methods:

  • GWAS data for omega-3, omega-6 fatty acids, DHA, LA, and other PUFAs (otPUFA) were used.
  • Large sample sizes for CKD (480,698) and eGFR (1,201,909) were analyzed.
  • MR methods including IVW, MR-PRESSO, weighted median, and MR-Egger regression were applied.

Main Results:

  • Suggestive evidence indicated higher omega-6 fatty acids associated with increased eGFR (β: 0.005; 95% CI: 0.002, 0.008).
  • Higher linoleic acid (LA) levels were associated with increased eGFR (β: 0.005; 95% CI: 0.003, 0.007).
  • No significant associations were found for other PUFAs or in the reverse direction.

Conclusions:

  • Higher omega-6 fatty acids and LA may contribute to increased eGFR.
  • Findings suggest potential public health relevance for omega-6 fatty acids in kidney function.
  • Further longitudinal studies or RCTs are recommended.