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Related Experiment Video

Updated: Aug 10, 2025

Whole Vitreous Humor Dissection for Vitreodynamic Analysis
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Ultrasonic Vitrectomy Performance Assessment Using Micro-Extensional Rheology.

John C P Hollister1, Mercedes Rodriguez2, Helia Hosseini3

  • 1Department of Mechanical and Aerospace Engineering, University of California - Los Angeles, Los Angeles, CA, USA.

Translational Vision Science & Technology
|February 15, 2023
PubMed
Summary

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This summary is machine-generated.

Ultrasonic (US) vitrectomy devices create smaller vitreous fragments than pneumatic blade (PB) cutters, as shown by micro-extensional rheology. This enhanced fragmentation may improve retina safety during vitreo-retinal surgery.

Area of Science:

  • Ophthalmology and Biomedical Engineering
  • Materials Science and Biomaterials

Background:

  • Vitreo-retinal surgery utilizes vitrectomy devices to remove vitreous humor.
  • Conventional pneumatic blade (PB) cutters are standard, but newer ultrasonic (US) vitrectomy devices offer potential advantages.
  • Assessing the impact of different vitrectomy technologies on vitreous tissue properties is crucial for surgical safety and efficacy.

Purpose of the Study:

  • To quantitatively compare the effects of ultrasonic (US) vitrectomy and conventional pneumatic blade (PB) cutters on extracted vitreous properties.
  • To utilize micro-extensional rheology to analyze the fragmentation of vitreous humor by these devices.

Main Methods:

  • Thirty-six porcine vitreous samples were extracted using both US and PB vitrectomy devices.
  • Micro-extensional rheology was employed to measure extensional relaxation times, inferring protein fragment size.

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  • Samples were tested within 24 hours postmortem and 4 hours post-vitrectomy at 4°C.

    • Main Results:

    • US-extracted vitreous showed significantly lower extensional relaxation times (0.37 ms) compared to PB-extracted vitreous (27.25 ms).
    • Lower relaxation times indicate smaller collagen fiber fragments.
    • PB-extracted samples displayed "beads-on-a-string" droplets, signifying larger fragments, which were absent in US samples.

    Conclusions:

    • Micro-extensional rheology effectively differentiates the physical properties of vitreous extracted by US and PB devices.
    • PB vitrectomy results in larger vitreous fragments, evidenced by longer relaxation times and droplet formation.
    • US vitrectomy yields higher vitreous fragmentation with smaller protein fragments.