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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Related Experiment Video

Updated: Aug 10, 2025

Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions
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A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial):

Katell Le Du1, Anne-Lise Septans2, Frédéric Maloisel3

  • 1Department of Hematology, Confluent Private Hospital, Nantes, France.

Journal of Medical Internet Research
|February 15, 2023
PubMed
Summary

Virtual reality (VR) distraction effectively reduced pain during bone marrow biopsies, showing comparable results to standard treatments. This VR therapy offers a well-tolerated alternative for pain management in oncology patients.

Keywords:
RCTVRbiopsybone marrowclinical trialdigital healthdigital therapeuticsdistractioneHealtheffectivenessefficacyhead-mounted displayimageryimaginaryimaginationimmersive environmentinteractive environmentmedical procedurepainrandomized controlled trialsafetysatisfactionvirtual reality

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Area of Science:

  • Oncology
  • Pain Management
  • Medical Technology

Background:

  • Virtual reality (VR) shows promise for pain relief in clinical settings.
  • Previous phase 2 trials suggest VR distraction can be effective for procedural pain.
  • Large-scale randomized trials comparing VR to standard treatments are needed.

Purpose of the Study:

  • To evaluate the safety and efficacy of a novel VR therapy for pain distraction during bone marrow biopsy.
  • To compare VR therapy with a standard treatment (mixture of nitrous oxide/oxygen - MEOPA) for pain management.

Main Methods:

  • An open-label, multicenter, randomized phase 3 trial involving 126 patients undergoing bone marrow biopsy.
  • Patients were assigned to either VR distraction or MEOPA for pain prevention, alongside local anesthesia.
  • Pain intensity was measured using a visual analog scale (VAS); anxiety and tolerance were secondary endpoints.

Main Results:

  • No significant difference in pain intensity was found between the VR group (3.0) and the MEOPA group (3.5) (P=.26).
  • Anxiety levels before and after the procedure were similar between groups.
  • VR was well-tolerated by 95% of patients and received high satisfaction ratings from patients, nurses, and physicians.

Conclusions:

  • VR distraction is a safe and effective alternative for managing pain during bone marrow biopsies.
  • VR offers a viable option for patients with contraindications or intolerance to MEOPA.
  • High patient and clinician satisfaction suggests VR can be integrated into routine care.