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Cell cycle oscillations driven by two interlinked bistable switches.

Pedro Parra-Rivas1, Daniel Ruiz-Reynés2, Lendert Gelens2

  • 1Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni, Sapienza Universitá di Roma, 00184 Rome, Italy.

Molecular Biology of the Cell
|February 15, 2023
PubMed
Summary
This summary is machine-generated.

Cell cycle oscillations are regulated by cyclin B-Cdk1 feedback. Bistable switches in this network enhance oscillation properties and robustness, as shown through modeling and bifurcation analysis.

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Area of Science:

  • Cell Biology
  • Systems Biology
  • Biophysics

Background:

  • Cell cycle progression relies on regulated transitions between interphase and mitosis.
  • The cyclin B-Cdk1 complex is a key regulator, with its activity driving cell cycle oscillations.
  • Negative feedback, where active cyclin B-Cdk1 promotes cyclin B degradation, forms the basis of this oscillator.

Purpose of the Study:

  • To investigate how bistable switches in the cell cycle regulatory network influence oscillation properties.
  • To determine if bistable switches can confer robustness to the cell cycle oscillator.
  • To analyze the impact of single and multiple bistable switches on cell cycle dynamics.

Main Methods:

  • Development of mathematical models for cell cycle oscillators.
  • Experimental identification of positive-feedback loops and bistable switches in *Xenopus laevis* embryos.
  • Detailed bifurcation analysis of the developed models.

Main Results:

  • Single and multiple bistable switches alter the characteristics of cell cycle oscillations.
  • Bistable switches can enhance the robustness of the cell cycle oscillator.
  • Bifurcation analysis revealed specific parameter dependencies of oscillation properties.

Conclusions:

  • Bistable switches are crucial for modulating cell cycle oscillator behavior.
  • The presence of bistable switches contributes to the stability and reliability of cell cycle progression.
  • Mathematical modeling and bifurcation analysis provide insights into the complex regulatory mechanisms of the cell cycle.