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Updated: Aug 9, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
[Neuroleptic malignant syndrome - unexpected complication in a COVID-19 patient]
Jiří Sagan1, Martin Hýža, Tomáš Skřont
1Department of Infectious Diseases, Faculty Hospital Ostrava and Faculty of Medicine, University of Ostrava, Czech Repubic,
Abstract:
Neuroleptic malignant syndrome is a life-threatening condition that can be fatal if unrecognized and inadequately treated. This disease is rarely seen in infectious diseases wards. As infectiologists, however, we are confronted with an increasingly broader spectrum of diagnoses and this disease should therefore be considered in any patient taking psychiatric medication who develops the typical symptoms of hyperthermia, rigidity and muscle tremors, autonomic lability and impaired consciousness. A case report is presented of a young man with schizophrenia admitted to the intensive care unit with COVID-19, who was treated with antipsychotics (formerly known as neuroleptics) for restlessness and who developed neuroleptic malignant syndrome. In cooperation with psychiatrists, a targeted therapy was initiated, after which the symptoms subsided and the patient's clinical condition resolved.
Insights
Neuroleptic malignant syndrome is a rare but life-threatening condition. Early recognition and treatment are crucial, especially in patients with COVID-19 and those on antipsychotic medications.
Area of Science:
- Medicine
- Infectious Diseases
- Psychiatry
Background:
- Neuroleptic malignant syndrome (NMS) is a rare, life-threatening condition associated with antipsychotic medication.
- While typically seen in psychiatric settings, NMS can present in infectious disease wards.
- Infectious disease specialists must consider NMS in patients with psychiatric medication history and characteristic symptoms.
Observation:
- A case of NMS occurred in a young male patient with schizophrenia admitted for COVID-19.
- The patient developed NMS symptoms after receiving antipsychotics for restlessness.
- This highlights the potential for NMS in critically ill patients on psychiatric medication.
Findings:
- The patient presented with hyperthermia, rigidity, autonomic lability, and impaired consciousness.
- Prompt, targeted therapy was initiated in collaboration with psychiatric specialists.
- The patient's NMS symptoms resolved, and his clinical condition improved.
Implications:
- This case underscores the importance of considering NMS in diverse clinical settings, including infectious disease and intensive care units.
- Collaboration between infectious disease and psychiatric teams is vital for effective NMS management.
- Awareness of NMS in patients with COVID-19 and on antipsychotics can improve patient outcomes.
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