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Multisystemic eosinophilic epitheliotropic disease in three donkeys.
Georgios Paraschou1, Polly E Vogel2, Alison M Lee3
1Pathology Laboratory, The Donkey Sanctuary, Brookfield Farm, Offwell, Honiton, Devon, UK; Department of Pathobiology & Population Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, UK; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
Multisystemic eosinophilic epitheliotropic disease (MEED) is a rare equine condition. This study documents MEED in three donkeys, a species not previously reported with this disease, highlighting new findings in equine pathology.
Area of Science:
- Veterinary Pathology
- Equine Medicine
- Dermatology
Background:
- Multisystemic eosinophilic epitheliotropic disease (MEED) is a rare condition affecting equids.
- It is characterized by eosinophilic infiltration across multiple organ systems.
- Reported cases are predominantly in horses, with limited documentation in other equid species.
Purpose of the Study:
- To document the clinical and pathological findings of MEED in three donkeys.
- To report MEED in donkeys for the first time.
- To contribute to the understanding of MEED in a less commonly affected equid species.
Main Methods:
- Case documentation of three donkeys presenting with weight loss, lethargy, exfoliative dermatitis, and peripheral eosinophilia.
- Clinical and post-mortem examinations were performed.
- Histopathological analysis of affected organs to identify eosinophilic infiltrates and granulomas.
Main Results:
- All three donkeys exhibited fluctuating or chronic weight loss, lethargy, and exfoliative dermatitis.
- Post-mortem examinations revealed multifocal eosinophilic infiltrates and granulomas in various organs.
- Peripheral eosinophilia was noted in affected animals.
Conclusions:
- This study confirms Multisystemic eosinophilic epitheliotropic disease (MEED) in donkeys, a novel finding.
- The clinical and pathological presentation in donkeys shares similarities with horses but expands the known host range for MEED.
- Further research is needed to understand the pathogenesis and potential treatments for MEED in equids.
