[Advances in the Study of Chemokine-like Factor Superfamily Members in Tumors]

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Gang Xie1, Jing Cheng1, Junping Zhang1

  • 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|February 15, 2023
PubMed

Insights

Chemokine-like factor-like MARVEL transmembrane domain containing member (CMTM) proteins are implicated in cancer development, growth, and immune evasion. CMTM4/CMTM6 regulate PD-L1, highlighting their potential as cancer drug targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Chemokine-like factor-like MARVEL transmembrane domain containing member (CMTM/CKLFSF) proteins link chemokines and transmembrane superfamilies.
  • CMTMs exhibit broad chemotactic activities and are closely associated with the hematopoietic and immune systems, as well as tumor development and metastasis.

Approach:

  • This review synthesizes current research on the role of CMTM family members in cancer.
  • It specifically examines their involvement in tumor growth, metastasis, and immune escape.
  • The paper highlights recent findings concerning CMTM and non-small cell lung cancer.

Key Points:

  • CMTM proteins are integral to key cancer development processes, including growth factor receptor regulation, cell proliferation, metastasis, and tumor immune microenvironment modulation.
  • CMTM4 and CMTM6 are identified as regulators of programmed cell death ligand 1 (PD-L1), a critical factor in tumor immune evasion.
  • The study emphasizes the emerging understanding of CMTM's role in cancer biology.

Conclusions:

  • CMTM family members play a significant role in various aspects of cancer progression and immune response.
  • CMTMs represent a promising area for novel cancer therapeutic strategies and biomarker development.
  • Further research into CMTM's clinical value, particularly in non-small cell lung cancer, is warranted.
Keywords:
BiomarkerCKLFCMTMChemokine-like factorTumor

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