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Apolipoprotein E phenotype and gene distribution in The Netherlands
E C Klasen1, M Smit, P de Kniff
1Department of Human Genetics, Sylvius Laboratories, State University, Leiden, The Netherlands.
Human Heredity
|January 1, 1987
Summary
Apolipoprotein E (APOE) gene frequencies in 2,000 Dutch men were analyzed. Results showed APOE phenotype distribution similar to other populations, but a lower frequency of the APOE epsilon 4 allele compared to Finns.
Area of Science:
- Human genetics
- Population genetics
- Biochemistry
Background:
- Apolipoprotein E (APOE) plays a crucial role in lipid metabolism and is associated with various health conditions.
- Understanding the distribution of APOE gene variants in different populations is essential for genetic and epidemiological studies.
Purpose of the Study:
- To determine the apolipoprotein E (APOE) gene frequencies and phenotype distribution in a Dutch male population.
- To compare these findings with previously studied populations.
Main Methods:
- Phenotyping for apolipoprotein E was performed on 2,000 randomly selected male individuals from three distinct regions in The Netherlands.
- Statistical analysis was used to compare gene frequencies and phenotype distributions.
Main Results:
- The apolipoprotein E gene frequencies and phenotype distribution in the studied Dutch population were largely consistent with those reported in other populations.
- A significant exception was observed: the frequency of the APOE epsilon 4 allele was notably lower in this Dutch cohort compared to the Finnish population.
Conclusions:
- The APOE genotype distribution in The Netherlands is generally similar to other European populations.
- The lower observed frequency of the APOE epsilon 4 allele in Dutch males warrants further investigation and comparison with other Northern European cohorts.