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Published on: September 12, 2014
Pterygium surgery with lyophilized versus cryopreserved amniotic membrane graft
N Sabater-Cruz1, M Figueras-Roca2, E M Martinez-Conesa3
1Hospital Clinic de Barcelona, Barcelona, Spain; Hospital Universitari Sagrat Cor, Barcelona, Spain; Barcelona Tissue Bank (BST-BTB), Barcelona, Spain; Admiravision, Barcelona, Spain.
Purpose:
To evaluate surgical outcomes (recurrence rate, aesthetics and symptoms) of pterygium surgery with two different amniotic membrane preservation approaches - lyophilized (LAM) and cryopreserved (CAM).
Methods:
Primary pterygium patients were randomized to either LAM or CAM surgery. Demographic data, ocular surface disease index (OSDI), aesthetic grading (1 to 4), recurrences and complications were recorded over a 6-month follow-up period.
Results:
Twenty-nine patients were recruited. Recurrence at month 6 was detected in 11 cases (37.9%) and was more prevalent with CAM grafts, without reaching statistical significance (P=0.196). Aesthetic outcome grading showed no differences between LAM and CAM at month 6 (P=0.124). Aesthetic results were mostly unsatisfactory (grade 3 and 4) without statistical differences between groups (P=0.514). Baseline OSDI was similar in both groups (P=0.888), and it significantly decreased by the last follow-up visit (P<0.001) for both the LAM and CAM groups. This decrease did not significantly differ between amniotic membrane preservation approach surgery groups (P=0.714).
Conclusion:
LAM might be considered a legitimate alternative to CAM, showing no inferiority in outcomes, since clinical and aesthetic outcomes were similar for both groups.
