Related Experiment Video
Updated: Aug 9, 2025
05:01
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
464
Breathing easy: Dopamine quenches the ILC2 flame
1National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Immunity
|February 15, 2023
Summary
Dopamine inhibits group 2 innate lymphoid cells (ILC2s) by restricting their metabolism. This finding reveals a new mechanism for controlling allergic airway inflammation and asthma.
Area of Science:
- Immunology
- Neuroscience
- Metabolism
Background:
- Nerve-innate lymphoid cell interactions regulate allergic airway inflammation.
- The precise molecular mechanisms remain largely undefined.
Purpose of the Study:
- To elucidate the role of neural communication in modulating group 2 innate lymphoid cell (ILC2) function.
- To identify molecular targets for treating allergic airway diseases.
Main Methods:
- Investigated the impact of neural signals on ILC2s.
- Analyzed the metabolic pathways of ILC2s in the context of inflammation.
- Assessed the therapeutic potential of targeting these pathways.
Main Results:
- Identified dopamine as a key inhibitory signal from nerves to ILC2s.
- Demonstrated that dopamine restricts ILC2 metabolic activity.
- Showed that dopamine ameliorates allergic airway inflammation and asthma features.
Conclusions:
- Dopamine plays a critical role in suppressing ILC2-driven allergic inflammation.
- Metabolic restriction of ILC2s by dopamine offers a novel therapeutic strategy for asthma.
Related Concept Videos
01:22Physiology of Respiration II: Neurogenic Control of Respiration
741
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
741
01:18Neural Control of Respiration
2.7K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
2.7K
01:23Physiological Control of Respiration
2.2K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.2K
01:18Respiratory Regulation of Acid-Base Balance
527
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
527
01:17Gross Anatomy of the Lungs
2.4K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
2.4K
01:31Chemical Factors Affecting Respiration Centers
1.2K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
1.2K