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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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The Neutrophil-to-Lymphocyte Ratio as a Predictor of Postoperative Outcomes in Patients Undergoing Coronary Artery

Hyun Ah Lim1, Joon Kyu Kang2, Hwan Wook Kim1

  • 1Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Journal of Chest Surgery
|February 15, 2023
PubMed

Insights

High preoperative neutrophil-to-lymphocyte ratio (NLR) is linked to increased early mortality after coronary artery bypass grafting (CABG). This finding highlights NLR as a potential predictive marker for cardiovascular surgery outcomes.

Area of Science:

  • Cardiology
  • Hematology
  • Surgical Outcomes

Background:

  • Neutrophil-to-lymphocyte ratio (NLR) is a proposed biomarker for cardiovascular disease.
  • The prognostic significance of NLR in patients undergoing coronary artery bypass grafting (CABG) remains uncertain.

Purpose of the Study:

  • To investigate the association between preoperative NLR and early mortality in patients undergoing isolated CABG.
  • To determine if NLR can serve as a predictive marker for adverse outcomes post-CABG.

Main Methods:

  • Retrospective analysis of 920 patients undergoing isolated CABG.
  • Logistic regression analysis to identify risk factors for 30- and 90-day mortality.
  • Comparison of mortality rates between high (≥3.4) and low (<3.4) NLR groups based on ROC curve analysis.

Main Results:

  • Preoperative NLR was significantly associated with both 30-day (OR 1.28) and 90-day (OR 1.17) mortality.
  • Patients in the high NLR group (≥3.4) exhibited substantially higher 30-day (12.1% vs 1.4%) and 90-day (21.3% vs 2.8%) mortality rates compared to the low NLR group.
  • An optimal cut-off value for preoperative NLR predicting mortality was identified as 3.4.

Conclusions:

  • Preoperative NLR is a strong predictor of early mortality following isolated CABG.
  • Elevated NLR (≥3.4) identifies patients at significantly higher risk for early death after CABG.
  • Further validation in larger cohorts is recommended to confirm these findings.
Abstract

Keywords:
Coronary artery bypassCoronary artery diseaseNeutrophil to lymphocyte ratio

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