β-Cyclodextrin: a green supramolecular catalyst assisted eco-friendly one-pot three-component synthesis of
Subhankar Paul1, Sharmistha Das1, Bijeta Mitra1
1Department of Chemistry, University of North Bengal District-Darjeeling West Bengal India pizy12@yahoo.com +91 0353 2699001 +91 0353 2776381.
Abstract:
A green, novel and eco-efficient synthetic route towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular solid as a green and eco-benign catalyst at room temperature under water-ethanol solvent medium. The exploration of the green catalyst β-cyclodextrin for the metal-free one-pot three-component synthesis of a wide range of highly functionalized bio-active heterocyclic pyrrolidine-2-one moieties from easily available aldehydes and amines explains the superiority and uniqueness of this protocol.
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