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The pig as an animal model for the study of nitrosamine metabolism

G W Harrington1, P N Magee, H M Pylypiw

  • 1Department of Chemistry, Temple University, Philadelphia, PA 19122.

IARC Scientific Publications
|January 1, 1987
PubMed

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2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.