Related Experiment Videos
Could N-nitrosamino phosphates be transport forms of activated N-nitrosamines?
N Frank1, M Wiessler, B L Pool
1Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
IARC Scientific Publications
|January 1, 1987
Abstract:
The stability of N-nitroso-N-methylamine-N-ethyl phosphate (NMEP) and N-nitroso-N-ethylamine-N-ethyl phosphate (NEEP) was studied in rat serum and in rat liver homogenate and found to be sufficiently high for the phosphates to be transported in vivo. In liver homogenates, the cleavage was more efficient, and a higher phosphatase activity was found in liver microsomal and cytosolic fractions than in serum. The substances exert a distinct activity in the Salmonella typhimurium mutagenicity test.