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Challenges and future of HER2-positive gastric cancer therapy

Chenzhe Ma1,2, Xiao Wang1,2, Jiwu Guo1,2

  • 1The Second Clinical Medical College, Lanzhou University, Lanzhou,  China.

Frontiers in Oncology
|February 16, 2023
PubMed

Insights

Advanced gastric cancer treatment is challenging. This review explores new drugs targeting human epidermal growth factor receptor 2 (HER2)-positive cancers and discusses trastuzumab resistance, offering insights into novel therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Gastric cancer is a leading cause of cancer death globally, with limited treatment options for advanced stages.
  • Human epidermal growth factor receptor 2 (HER2) is implicated in cancer progression and poor prognosis.
  • Trastuzumab, a HER2-targeted therapy, is a first-line treatment for HER2-positive advanced gastric cancer, but resistance is a growing concern.

Purpose of the Study:

  • To review the mechanisms of action for emerging HER2-targeted therapies in gastric cancer.
  • To discuss novel detection techniques for HER2-positive advanced gastric cancer.
  • To address the challenge of trastuzumab resistance in HER2-positive gastric cancer treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on HER2-targeted therapies.
  • Analysis of drug mechanisms and resistance pathways.
  • Examination of advancements in diagnostic and detection methods for HER2-positive gastric cancer.

Main Results:

  • Trastuzumab resistance necessitates the development of alternative and combination HER2-targeted treatments.
  • Emerging therapies target various aspects of HER2 signaling pathways.
  • Improved detection methods enhance patient stratification for targeted therapies.

Conclusions:

  • Targeted therapy, particularly against HER2, offers a promising avenue for advanced gastric cancer.
  • Overcoming trastuzumab resistance is crucial for improving patient outcomes.
  • Continued research into novel HER2-targeting drugs and detection strategies is essential for advancing gastric cancer treatment.
Keywords:
HER2Her2 resistancegastric cancerreceptor ErbB-2trastuzumab

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