Acquired reactive perforating collagenosis combined with MRSA: A case report
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Updated: Aug 9, 2025
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Fuqian Huang1, Weiqi Ren1, Miaomiao Wang1
1Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Abstract:
Acquired reactive perforating collagenosis (ARPC) is a rare chronic skin disease associated with various internal diseases, particularly diabetes and chronic renal failure. The present study describes the case of a patient with ARPC combined with methicillin-resistant Staphylococcus aureus (MRSA), in an aim to broaden the current understanding of ARPC. A 75-year-old female presented with a 5-year history of pruritus and ulcerative eruptions on the trunk of her body, which became more severe within 1 year. A cutaneous examination revealed a diffuse distribution of erythema and papules, and nodules of various sizes, some of which sagged at the center and had a dark brown crust. A histopathological analysis revealed typical perforations of the collagen fibers. The patient was initially treated with topical corticosteroids and oral antihistamines for skin lesions and pruritus. Medications for glucose control were also administered. Upon the second admission, a combination of antibiotics and acitretin was added. The keratin plug shrank, and the pruritus was relieved. To date, to the best of our knowledge, this is the first reported case of concurrent ARPC and MRSA.
Insights
Acquired reactive perforating collagenosis (ARPC) is a rare skin condition. This case study details the first known instance of ARPC concurrently with methicillin-resistant Staphylococcus aureus (MRSA) infection.
Area of Science:
- Dermatology
- Infectious Diseases
Background:
- Acquired reactive perforating collagenosis (ARPC) is a rare chronic dermatosis.
- ARPC is frequently associated with systemic conditions like diabetes mellitus and chronic renal failure.
Observation:
- A 75-year-old female presented with a 5-year history of pruritus and ulcerative skin eruptions.
- Clinical examination revealed erythema, papules, and nodules with central sagging and crusting.
- Histopathology confirmed characteristic perforations of collagen fibers.
Findings:
- The patient had concurrent ARPC and methicillin-resistant Staphylococcus aureus (MRSA) infection.
- Treatment with topical corticosteroids, antihistamines, glucose control, antibiotics, and acitretin led to symptom improvement.
- Keratin plug reduction and pruritus relief were observed.
Implications:
- This case represents the first documented instance of ARPC co-occurring with MRSA.
- Highlights the importance of considering infectious complications in ARPC management.
- Contributes to a broader understanding of ARPC's clinical spectrum and management strategies.
