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Effect of ascorbic acid on the metabolism of N-nitrosopiperidine
M Nakamura1, Y Osada, Y Horiguchi
1Kanagawa Prefectural Public Health Laboratory, Yokohama, Japan.
IARC Scientific Publications
|January 1, 1987
Abstract:
Guinea-pigs were fed diets containing 48, 200 or 2000 mg/kg ascorbic acid (AsA) for 20-30 days and given a single oral dose of 50 mg N-nitrosopiperidine (NPIP)/kg body weight. The levels of glutaric acid, 3-hydroxy-NPIP and 4-hydroxy-NPIP, but not of 1,5-pentanediol, in urine increased with the dose of AsA in the diet.