Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same author

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

Neurology·2026
Same author

Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling.

Science advances·2026
Same author

Proteomic Signatures of 3-Year Progression From Impaired Fasting Glucose to Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.

Diabetes care·2026
Same author

Blood-based proteomic signature of amyloidosis: identification of novel regulators of amyloid load.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.

Cell reports·2026
Same journal

Age-related molecular changes that are exercise independent.

Nature aging·2026
Same journal

Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle.

Nature aging·2026
Same journal

Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice.

Nature aging·2026
Same journal

Mapping the network architecture of aging to identify repurposable drug candidates for longevity.

Nature aging·2026
Same journal

Targeting interleukin-11 to slow ovarian aging.

Nature aging·2026
Same journal

Modulating IL-11-dependent matrix stiffness to delay ovarian aging.

Nature aging·2026
See all related articles

Related Experiment Video

Updated: Aug 9, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.9K

Reducing decoys focuses fighting microglia.

Michael R Duggan1, Keenan A Walker1

  • 1Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.

Nature Aging
|February 16, 2023
PubMed
Summary
This summary is machine-generated.

Genetic variations lowering soluble ST2, a receptor for IL-33, may protect female APOEε4 carriers from Alzheimer's disease by enhancing microglial plaque clearance. This highlights sex-specific immune roles in neurodegeneration.

More Related Videos

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation
10:21

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

19.4K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

3.6K

Related Experiment Videos

Last Updated: Aug 9, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.9K
Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation
10:21

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

19.4K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

3.6K

Area of Science:

  • Neuroimmunology
  • Genetics of Alzheimer's Disease

Background:

  • Alzheimer's disease (AD) pathogenesis involves complex interplay between genetics and immune responses.
  • The apolipoprotein E ε4 allele (APOEε4) is a major genetic risk factor for AD, particularly in women.
  • Soluble ST2 (sST2), a decoy receptor for interleukin-33 (IL-33), plays a role in immune regulation, but its specific involvement in AD is not fully understood.

Purpose of the Study:

  • To investigate the association between genetic variations in the IL33/ST2 pathway and Alzheimer's disease risk.
  • To explore potential sex-specific effects of these genetic variations on AD pathology, specifically in APOEε4 carriers.
  • To determine if genetic modulation of the IL-33/ST2 axis influences microglial function in Alzheimer's disease.

Main Methods:

  • Analysis of genetic variations within the IL33 and ST2 genes in a cohort of individuals with and without Alzheimer's disease.
  • Measurement of soluble ST2 (sST2) levels in serum or cerebrospinal fluid.
  • Assessment of microglial activation and amyloid-beta plaque burden in brain imaging or post-mortem tissue, stratified by sex and APOEε4 carrier status.

Main Results:

  • Specific genetic variations associated with lower sST2 levels were identified.
  • Lower sST2 levels were linked to a reduced risk of Alzheimer's disease, particularly in female APOEε4 carriers.
  • These genetic variations correlated with increased microglial-mediated clearance of amyloid-beta plaques.

Conclusions:

  • Genetic modulation of the IL-33/ST2 pathway, leading to lower sST2, offers a potential protective mechanism against Alzheimer's disease in a specific demographic (female APOEε4 carriers).
  • The findings suggest that enhancing microglial plaque removal via this pathway could be a therapeutic strategy.
  • This research underscores the critical importance of considering sex-specific differences in immune system function when studying Alzheimer's disease.