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Reducing decoys focuses fighting microglia
Michael R Duggan1, Keenan A Walker1
1Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Nature Aging
|February 16, 2023
Abstract:
Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimer's disease in female APOEε4 carriers by increasing microglial plaque removal. This discovery advances our understanding of the immune system's role in Alzheimer's disease and underscores the importance of sex-specific disease processes.
