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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Association between Decreased Estimated Glomerular Filtration Rates and Long-term Mortality in Korean Patients with

Mi Sook Oh1,2, Seong Woo Choi1,3, Myung Ho Jeong2

  • 1Department of Public Health, Graduate School of Chosun University, Gwangju, Korea.

Chonnam Medical Journal
|February 16, 2023
PubMed

Insights

Reduced kidney function (eGFR) predicts mortality in acute myocardial infarction (AMI) patients. The CKD-EPI equation is more effective than MDRD for predicting 3-year mortality in AMI survivors.

Area of Science:

  • Cardiology
  • Nephrology
  • Epidemiology

Background:

  • Reduced estimated glomerular filtration rate (eGFR) is a known predictor of mortality in patients with acute myocardial infarction (AMI).
  • Understanding the impact of different eGFR calculation methods on mortality prediction is crucial for patient management.

Purpose of the Study:

  • To compare the predictive value of GFR and eGFR calculation methods for long-term mortality in AMI patients.
  • To evaluate the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in predicting 3-year mortality.

Main Methods:

  • Analysis of data from the Korean Acute Myocardial Infarction Registry-National Institutes of Health.
  • Inclusion of 13,021 AMI patients, divided into surviving and deceased groups.
  • Calculation of eGFR using CKD-EPI and MDRD equations; analysis of clinical characteristics and risk factors.

Main Results:

  • The deceased group was significantly older and had higher prevalences of hypertension and diabetes.
  • Lower eGFR was significantly associated with increased 3-year mortality (p<0.001).
  • The CKD-EPI equation demonstrated superior predictive accuracy for mortality compared to the MDRD equation (0.766 vs. 0.738, p=0.001).

Conclusions:

  • Decreased renal function, indicated by reduced eGFR, is a significant independent predictor of 3-year mortality in AMI patients.
  • The CKD-EPI equation is more effective than the MDRD equation for predicting mortality in this patient population.

Keywords:
Glomerular Filtration RateMyocardial InfarctionRenal Insufficiency, Chronic

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