Recent advances in peptide-based therapeutic strategies for breast cancer treatment

Area of Science:

• Oncology
• Biotechnology
• Pharmacology

Background:

• Breast cancer remains a leading cause of cancer-related deaths globally in women.
• There is an urgent need for effective breast cancer therapies with minimal side effects.
• Peptide-based strategies show significant promise due to their safety and adaptability.

Purpose of the Study:

• To review current research on peptide-based approaches for breast cancer therapy and prevention.
• To explore the role of peptide targeting vectors, cell penetrating peptides (CPPs), vaccines, and anticancer peptides.

Main Methods:

• Review of existing scientific literature on peptide-based breast cancer treatments.
• Analysis of studies focusing on peptide targeting vectors and their specific receptor binding.
• Examination of cell penetrating peptides (CPPs) for enhanced cellular internalization.
• Overview of peptide-based vaccines in various clinical trial phases.
• Investigation of novel anticancer peptides and their mechanisms of action.

Main Results:

• Peptide-based vectors demonstrate specific binding to overexpressed breast cancer receptors.
• Cell penetrating peptides (CPPs) enhance cellular uptake through electrostatic and hydrophobic interactions.
• Numerous peptide-based vaccines are in clinical trials, with some already implemented with delivery vectors and adjuvants.
• Several peptides are in clinical use, exhibiting diverse anticancer mechanisms and overcoming resistance.

Conclusions:

• Peptide-based strategies are highly promising for breast cancer therapy and prevention.
• Further development of peptide targeting vectors, CPPs, vaccines, and anticancer peptides is warranted.
• These peptide-based approaches offer a safer alternative with potential to improve patient outcomes.